Without this external, stabilizing protein network, the AMPA receptors are no longer retained at the synapse, leading to weak, short-lived synaptic signals. The findings not only provide insight into ...

In this study, researchers used positron emission tomography and a special tracer to study the relationship between the distribution of an important neuronal receptor (AMPA) and the occurrence and ...

While the COVID pandemic has thankfully been over for some time now, there is still a considerable number of people in the world (about 400 million) suffering from long COVID. Long COVID is a chronic ...

Researchers headed by a team at Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health (CAMH) reported promising data from preclinical in vivo studies evaluating a ...

Most communication between neurons is mediated by the neurotransmitter glutamate. The finding that temperature influences how glutamate binds to neuronal receptor proteins to initiate signal ...

Three distinct snapshots obtained with cryo-electron microscopy illustrate the arrangement of two of the four symmetrical subunits that make a functional NMDA receptor. During activation, as the ...