The intricate interplay between heparan sulfate and the extracellular matrix is fundamental to tissue development, repair and disease modulation. Heparan sulfate, a complex glycosaminoglycan attached ...

Amyotrophic lateral sclerosis and frontotemporal dementia are heterogeneous diseases that are difficult to fully model in mice. One of the more common forms is caused by hexanucleotide repeat ...

Recently, a research team from Chongqing Medical University, led by Prof. Wei Huang, Dr. Wei Bao, and Dr. Yiting Lei, has successfully developed a novel engineered extracellular matrix (eECM) to ...

In cell and animal models of amyotrophic lateral sclerosis (ALS), the expression of toxic dipeptides in neurons led to changes in the extracellular matrix (ECM) as a protective response. The authors ...

Breast cancer cells (in blue) eating extracellular matrix (yellow). The bright white spots inside the cells are extracellular matrix components that are being digested by the cells, for them to obtain ...

Extracellular vesicles (EVs), including exosomes, microvesicles, apoptotic bodies, and many other EV subtypes, have emerged ...

This neon tapestry of red and blue is a unique look at the space between cells in the body known as the extracellular matrix. This image was created using a new labeling technique that allows ...