New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 28 (July 13, 2021), pp. 1-10 (10 pages) The evolutionary expansion of G protein-coupled receptors (GPCRs) ...

Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all phosphoevents ...

MINNEAPOLIS/ST. PAUL — New research led by the University of Minnesota Medical School demonstrates that molecules acting as “molecular bumpers” and “molecular glues” can rewire G protein-coupled ...

G protein-coupled receptors (GPCRs) represent a diverse group of signaling proteins and are involved in a wide variety of physiological processes. Of particular importance to the pharmaceutical ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their ...