Physician's Weekly

Clarifying a Common Critical Care Lab Test: Blood Lactate

COOH) represents the protonated form of the organic acid, whereas lactate (CH₃CH (OH)COO⁻) represents its conjugated base. This compound behaves as a weak acid with a pKa of approximately 3.86. In the ...
Case Western Reserve University

Lactate Metabolism, Signaling, and Function in Brain Development, Synaptic Plasticity, Angiogenesis, and Neurodegenerative Diseases

Abstract: Neural tissue requires a great metabolic demand despite negligible intrinsic energy stores. As a result, the central nervous system (CNS) depends upon a continuous influx of metabolic ...
Medscape

Elevated Lactate Dehydrogenase Levels Predict Worse Outcomes in Heart Failure With Reduced Ejection Fraction

Elevated baseline LDH levels predict worse clinical outcomes in heart failure with reduced ejection fraction and modestly ...
Nature

Ubiquinol-mediated suppression of mitochondria-associated ferroptosis is a targetable function of lactate dehydrogenase B in cancer

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...
ascopubs.org

Pretreatment levels of serum lactate dehydrogenase (LDH) and clinical outcome in metastatic colorectal cancer patients receiving first-line chemotherapy and bevacizumab.

The single-nucleotide polymorphism T>C rs4353229 in CASP7 gene and mir-224 as new biomarkers of oxaliplatin-induced neurotoxicity in advanced colorectal cancer. Background: No predictive marker for ...