A key approach to understanding the brain is to observe the behavioral effects of turning on specific populations of neurons. One of the most popular approaches to controlling neuronal activity in ...

Potassium channels are essential membrane proteins that enable the selective and rapid transport of K⁺ ions, a process fundamental to cellular excitability and signal transduction. Recent research has ...

G protein-coupled receptors (GPCRs) constitute one of the largest families of membrane proteins and play a pivotal role in translating extracellular signals into diverse intracellular responses. A key ...

Potassium channels can become nonconducting via inactivation at a gate inside the highly conserved selectivity filter (SF) region near the extracellular side of the membrane. In certain ligand-gated ...

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function with a 'ball-and-chain' channel-plugging mechanism. The findings boost the ...

Potassium channels are openings that allow charged potassium atoms to cross the cell membrane. Voltage-gated potassium channels — which open only when a specific voltage is reached across the cell ...

Molecular Devices, at SLAS 2015, launched a homogeneous, no-wash assay to measure ligand- and voltage-gated potassium channel activity. The FLIPR® Potassium Assay Kit uses a novel thallium-sensitive ...