Polysubstance use disorder is a mental health condition in which someone uses more than one substance at the same time or within a short period of time, despite a pattern of negative effects.

A massive survey recently released by a national drug-testing company strongly suggests we are well into the “fourth wave” of the opioid crisis. The three previous waves were driven by 1) prescription ...

As the overdose crisis continues to evolve across Appalachia, researchers at East Tennessee State University are diving into the complex science of polysubstance use to ...

Polysubstance use has become a defining feature of the U.S. overdose crisis in the past decade. While not every overdose involves multiple substances, a significant and growing proportion includes ...

Dispensaries in one of the first U.S. states to legalize recreational cannabis sales continue to disregard a law aimed at reducing the risk of consuming alcohol and cannabis simultaneously.

Most research suggests that opioid overdoses involving multiple substances in the United States typically occur among people ages 25-54. However, a new study led by Boston University School of Public ...